![]() ![]() 4 Approximately half of all HF patients have HF with mildly reduced ejection fraction (HFmrEF) or HF with preserved ejection fraction (HFpEF) 5 and these patients are not only at greater risk of death and hospitalisations but experience an especially high burden of symptoms and physical limitations, and a poor quality of life. 3 It is also the leading cause of hospitalisation for those over 65 years and represents a significant clinical and economic burden. HF is a chronic, long-term condition that worsens over time 2 and affects almost seven million people in the US. The approval of Farxiga in the US not only reinforces AstraZeneca’s commitment to reducing the burden of this complex and life-threatening disease, but will help patients across the full spectrum of heart failure lead healthier lives.” Ruud Dobber, Executive Vice-President, BioPharmaceuticals Business Unit, AstraZeneca, said: “Approximately half of heart failure patients die within five years of diagnosis, highlighting an urgent unmet need for well-tolerated treatment options that can bring life-saving benefits and reduce the risk of cardiovascular death. 1 Farxiga was previously approved in the US for adults with HF with reduced ejection fraction (HFrEF). The approval by the Food and Drug Administration (FDA) was based on positive results from the DELIVER Phase III trial.
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